Search results for "Structural alignment"

showing 3 items of 3 documents

Alignment of strategy and structure in local government

2020

Strategic positioning and structural alignment in the public sector is a neglected area of research. This paper analyses the strategic positions of prospectors, defenders and reactors and structural alignment in Norwegian municipalities. Top managers responding to a survey perceived that the municipalities did align their organizational structures to the strategic positions for prospectors and defenders, but not for reactors, as hypothesized, but these relationships were modest. The top managers often found it difficult to provide consistent responses on their organizations’ choices of strategic positions. The authors show that many Norwegian municipalities have minimal alignment of their o…

Organizational architecturePublic AdministrationSociology and Political ScienceStructural alignmentOrganizational designsStrategic positioningOrganizational performanceMunicipalitiesAccounting0502 economics and business050602 political science & public administrationOrganizational performancesIndustrial organizationStructure (mathematical logic)business.industryNorway05 social sciencesPublic sectorStrategic Choice050201 accountingGeneral Business Management and Accounting0506 political scienceLocal governmentStrategic choicesBusinessFinanceEnvironmental fits
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A novel approach to investigate the evolution of structured tandem repeat protein families by exon duplication.

2020

Tandem Repeat Proteins (TRPs) are ubiquitous in cells and are enriched in eukaryotes. They contributed to the evolution of organism complexity, specializing for functions that require quick adaptability such as immunity-related functions. To investigate the hypothesis of repeat protein evolution through exon duplication and rearrangement, we designed a tool to analyze the relationships between exon/intron patterns and structural symmetries. The tool allows comparison of the structure fragments as defined by exon/intron boundaries from Ensembl against the structural element repetitions from RepeatsDB. The all-against-all pairwise structural alignment between fragments and comparison of the t…

Protein familyStructural alignmentBiological data visualizationExonComputational biologyBiologyEvolution Molecular03 medical and health sciencesExonProtein structureTandem repeatStructural BiologyGene duplicationAnimalsHumans030304 developmental biology0303 health sciences030302 biochemistry & molecular biologyIntronProteinsExonsProtein superfamilyClassificationIntronsBiological data visualization; Classification; Exon; Protein evolution; Protein structure; Repeat proteinTandem Repeat SequencesRepeat proteinProtein structureProtein evolutionJournal of structural biology
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Assessment of the probabilities for evolutionary structural changes in protein folds.

2007

Abstract Motivation: The evolution of protein sequences can be described by a stepwise process, where each step involves changes of a few amino acids. In a similar manner, the evolution of protein folds can be at least partially described by an analogous process, where each step involves comparatively simple changes affecting few secondary structure elements. A number of such evolution steps, justified by biologically confirmed examples, have previously been proposed by other researchers. However, unlike the situation with sequences, as far as we know there have been no attempts to estimate the comparative probabilities for different kinds of such structural changes. Results: We have tried …

Statistics and ProbabilityModels MolecularProtein FoldingProtein domainStructural alignmentBiologyBiochemistrySet (abstract data type)Evolution MolecularProtein structureSimilarity (network science)Sequence Analysis ProteinComputer SimulationMolecular BiologyProtein secondary structureConserved SequenceSequenceModels GeneticSequence Homology Amino AcidProteinsStructural Classification of Proteins databaseComputer Science ApplicationsComputational MathematicsComputational Theory and MathematicsModels ChemicalData Interpretation Statisticalsense organsAlgorithmSequence AlignmentBioinformatics (Oxford, England)
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